Sep 29, 2016 · Although the clavulanic acid and thienamycin biosynthetic pathways have not been completely elucidated, enough is presently known to confidently ...
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The CEAS2 (Mr 62 kDa) is a protein with domains recognizing pyruvate and thiamine pyrophosphate and is similar (30% identity) to acetohydroxyacid synthases that ...
Dec 26, 2007 · The first committed biosynthetic step toward clavulanic acid, the clinically important beta-lactamase inhibitor, is catalyzed by the thiamin ...
Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined ...
Apr 24, 2013 · Clavulanic acid (CA) is a potent β-lactamase inhibitor produced by Streptomyces clavuligerus and has been successfully used in combination ...
This C-N bond forming reaction forms an unusual alpha, beta-unsaturated acyl-thiamine-pyrophosphate intermediate. This enzyme is the first gene in the ...
This is a potent nucleophile and can participate in covalent catalysis, particularly with α-keto (oxo) acid decarboxylase, α-keto acid oxidase, transketolase ...
Oct 30, 2013 · The first enzyme in this pathway, 1-deoxy-D-xylulose 5-phosphate (DXP) synthase, catalyzes a distinct thiamin diphosphate (ThDP)-dependent ...
Jul 27, 2022 · Thiamine pyrophosphate (TPP) is a vital ... identified inhibitors of thiamine phosphate synthase (ThiE) in ... novo amino acid synthesis as well.
In a novel N-C bond forming thiamine pyrophosphate-mediated reaction catalyzed by ORF2, encoded by the first gene of the clavulanic acid biosynthetic cluster, ...